SILiCON (Synthetic Images via a Linearly-weighted combination of CONtrasts)
SILiCON is a method for combining multiple MRI contrasts to create a unique tissue contrast for better visualization and tissue segmentation. T1-weighted (T1w) scans are commonly utilized to visualize the anatomical architecture of the brain because they provide excellent gray and white matter contrast. However, T1w scans lack contrast from subcortical structures such as the basal ganglia. The aim of this study is to establish a novel contrast that preserves T1w gray-white matter contrast while enhancing subcortical structural contrast.